Research has shown that achieving maximum natural growth hormone (GH) release by the anterior pituitary can be accomplished, in general, by combining a growth hormone releasing hormone (GHRH) ) analogue with a growth hormone secretagogue receptor (GHSR) agonist. There are multiple combinations that can accomplish this goal, including combining modified GRF . Of course, sometimes the goal might be to achieve more specific effects in addition to maximum GH release. In other words, by fine tuning the types of GHRH agonist and GHSR agonist used, it could be possible to create more targeted outcomes.

In the case of Modified GRF, a potent GHRH analogue, the effects go beyond simply boosting GH release. The peptide has been shown, in animal studies, to have benefits in intestinal inflammation, heart function, and wound healing.

By adding ipamorelin to the mix with modified GRF, GH release is pulsed to its maximum level. Ipamorelin, known for its specificity in boosting GH with few additional effects, has recently been linked to bone regrowth and matrix stabilization. These effects appear to be in addition to the bone benefits of enhanced GH release.

Finally, it is possible to boost targeted fat burning, something that both modified GRF and ipamorelin cause to a limited degree, with the aid of fragment 176-191. While technically a GHRH agonist, fragment 176-191 has been shown in animal models to be a primary and potent stimulator of adipocyte catabolism (fat burning). The peptide is orders of magnitude more potent than most GHRH agonists in stimulating fat metabolism and thus is sometimes referred to as the “lipolytic fragment.” Adding fragment 176-191 to the mix is a way to boost fat burning, particularly in the setting of enhanced GH release, and shift metabolism toward the accumulation of lean body mass.

Storage Instructions:

All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping 3-4 months reconstituted (mixed with bacteriostatic water) to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.

Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you're ready to reconstitute it with bacteriostatic water.

Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4C (39F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.

However, for longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80C (-112F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide’s stability.