Pal-GHK 200mg (Palmitoyl Tripeptide-1) (Topical)

Pal-GHK 200mg (Palmitoyl Tripeptide-1)

Pal-GHK (also called palmitoyl tripeptide-1 and palmitoyl oligopeptide) is a synthetic peptide known for its effects on collagen, skin health, and skin pigment. It is currently under investigation for its ability to boost collagen synthesis in animal models as well as for its ability to stimulate blood vessel growth.

Research Application:

Pal-GHK consists of a palmitic acid residue connected to a fragment of the elastin protein. This fragment, made of the amino acids glycine, histidine, and lysine, is sometimes referred to as GHK. GHK has been shown, in animal models, to stimulate fibroblast growth and reproduction, making if of particular interest for researchers interested in wound healing, skin repair, and tissue regeneration.

Pal-GHK is under active investigation for its ability to enhance skin strength, smoothness, and resilience in animal models. Though GHK is responsible for the actual effects, it is the palmitoyl component that makes it so potent. In fact, the attachment of palmitoyl to GHK is also being researched for its ability to boost skin and cell penetration in animal models, a property that could make the fatty acid useful in other creams and topical ointments in both cosmetic and medical applications.

What Is Pal-GHK?

Pal-GHK is a hybrid synthetic molecule made of one-part peptide and one-part fatty acid. The “Pal” segment of the name refers to palmitoyl, a well-known fatty acid and common component of mammalian cell membranes. The “GHK” component stands for the peptide sequence glycine-histidine-lysine. This is a small fraction of the much larger elastin protein and a potent stimulant of fibroblasts (cells that synthesize collage, elastin, and other important proteins in the extracellular matrix of skin, bone and other connective tissues). Pal-GHK is often included in research designs with other short peptides [1].

What Does Pal-GHK Do?

The GHK component of Pal-GHK tricks fibroblasts into thinking that elastin, a common skin protein, has been damaged. This induces the fibroblasts to grow and multiply so that they can regenerate what they think is the lost elastin in skin. In aging animals, fibroblasts tend to lose activity and become dormant. Studies in animal models indicate that GHK can re-energize fibroblasts and thus help to overcome some of the common effects that aging has on skin [2].

The Pal component of Pal-GHK is simply a vehicle. By attaching this fatty acid to a peptide sequence, it is possible to achieve greater skin and cell penetration in animal models. In other words, the job of Pal is to help GHK get to where it can be of most use – the inside of cells deep within the skin.

Pal-GHK Research on Reducing Wrinkles and Strengthening Skin

Pal-GHK has been shown, in animal models, to protect the skin from many of the effects of aging. In particular, Pal-GHK has been shown to boost collagen and elastin production [2]. It seems to be particularly useful for restoring lip moisture and fullness in animal models [3]. When combined with other short peptides, Pal-GHK can act synergistically to reduce the appearance of fine lines and wrinkles. It has even been shown to help reduce redness and discolored skin secondary to photodamage in animal studies [4,5].

Storage Instructions:

All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping 3-4 months reconstituted (mixed with bacteriostatic water) to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.

Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you're ready to reconstitute it with bacteriostatic water.

Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4C (39F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.

However, for longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80C (-112F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide’s stability.