Semax 10mg (Nasal)

Semax Overview

Semax, which was developed in Russia, has been found to have benefit in the settings of stroke, cognitive impairment, dementia, and inflammation of the optic nerve. It has also been tested as a potential immune system booster and has been found to have antidepressant and anxiolytic properties as well. Research shows thatincreases levels of brain-derived neurotrophic factor (BDNF) in the central nervous system as well as levels of serotonin and dopamine.

What Is Semax?

Semax is a synthetic analogue of adrenocorticotropic hormone (ACTH). It consists of the amino acids 4-10 of ACTH.

Semax Research

Semax Affects Resting Brain Structure

Functional magnetic resonance imaging has revealed that Semax boosts the function of what is called the default mode network. The default mode network refers to brain areas that are more active during rest than they are during active task performance. This particular network is actually poorly understood, but recent research suggests that it may play a role in social cognition and monitoring of the environment. It is like a general-purpose system for monitoring the world around us when we don’t have something specific to focus on. This makes it an important part of attention as the default mode network is necessary for rousing use from a “rest” state so that we can focus on an event, particularly events that involve relating to other people. In fact, the default mode network is often compromised in diseases of cognition, such as Alzheimer’s disease, which only further supports the idea that it is involved in general social awareness

By boosting activity in the default mode network, Semax serves to increase our general level of arousal while at rest. This makes us more attentive to our environment, particularly our social environment, which is perceived as have greater focus and attention. In other words, Semax may be enhancing basic environmental monitoring functions of the brain, allowing it to more readily shift from a resting state to a focused state.

Semax in the Setting of Stroke

Semax is used in Russia for the treatment of acute cerebral hypoxia, such as would be the case with stroke or traumatic brain injury. Research in rats has found Semax stimulates a number of molecular mechanisms involved in gene transcription in the central nervous system (CNS). In concrete terms, Semax stimulates changes in the expression of 24 different genes related to blood vessels function in the brain and spinal cord. These genes regulate everything from smooth muscle cell migration to red blood cell formation and the generation of new blood vessels. This correlation may explain why Semax has shown neuroprotective properties in the setting of stroke. It appears that the peptide promotes the survival of neurons, stabilizes mitochondria and thus energy production, and improves the supply of nutrition to the brainResearch carried out in Russia on patients involved in rehabilitation following a stroke indicates that the Semax accelerates the rate at which function returns and results in greater overall level of function at the completion of therapy

Semax and Cognitive Performance

There is reason to believe that Semax is an effective means of boosting learning and memory, particularly in individuals suffering from neurological impairment of these functions. According to research out of Canada, the United States, and China, ACTH, the natural protein on which Semax is based, protects learning and memory function in mouse models of epilepsy

According to Dr. Scantlebury, Semax is a very effective derivative of ACTH and may offer benefits that the natural peptide does not. Though more research needs to be done, he points out that ACTH, even at low doses, can prevent learning and memory dysfunction in the setting of seizure. This may, in turn, suggest that ACTH and Semax have nootropic properties and that they may be able to not only offset learning and memory deficits in the setting of disease, but may also boost cognitive performance if administered regularly and in low doses.

Semax and Depression

Research in mice has shown that increasing levels of BDNF can help to regulate the function of the brain in the setting of depression. Current antidepressants, like SSRIs, tend to indirectly affect serotonin signaling in the brain to achieve an effect, but several weeks of treatment are often required before any effect is seen. For years, this has presented a paradox to scientists who study brain chemistry because the effects should be much more immediate. Now, it appears, thanks to insight gained from Semax and other BDNF stimulating proteins, that SSRIs may take a long time to work because their actual therapeutic effect is related to their ability to increase BDNF levels and thus stimulate neurogenesis in the depressed brain. If this is true, it opens up an entirely new way of understanding depression and its treatment. According to Deltheil et. al., there is good reason to thank that combining BDNF stimulators, like Semax, with SSRI treatment could vastly improve efficacy and make it easier to treat depression. Of course, a great deal of research needs to be done to determine if these results can be replicated and extended.

Semax exhibits minimal side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. Semax for sale at Peptide Sciences is limited to educational and scientific research only, not for human consumption. Only buy Semax if you are a licensed researcher.

Storage Instructions:

All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping 3-4 months reconstituted (mixed with bacteriostatic water) to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.

Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you're ready to reconstitute it with bacteriostatic water.

Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4C (39F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.

However, for longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80C (-112F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide’s stability.