Syn-AKE 200mg (Topical)

Syn-AKE 200mg

Syn-AKE is the proprietary name of a peptide that is also referred to as tripeptide-3 or dipeptide diaminobutyroyl benzylamide diacetate. What makes Syn-AKE so interesting is that it is a protein fragment from the venom of the Malaysian Temple Viper. It is able to reduce signal transmission between nerves and muscles. It works in a manner similar to Botox to relax muscles and thus lessen wrinkles in skin in animal models [1].

Research Application:

Syn-AKE is under active investigation for its ability to reduce neuromuscular signaling in animal models and thus reduce muscle contractile activity. This action is similar to that of Botox and while Botox is often associated with cosmetic applications, the toxin (derived from bacteria) actually has multiple medical applications.

Botox is FDA-approved for treatment of things like prostate hyperplasia, smooth muscle disorders, Parkinson disease, depression, migraine headaches, dystonia, hemifacial spasms, and exocrine gland hyperactivity [2]. Peptides like Syn-AKE can be administered topically in animal models while Botox generally has to be injected. There is hope that topical neuromuscular antagonists may one day be used for some of the things that Botox is currently approved for, making administration easier and allowing for at-home use.

What Is Syn-AKE?

Syn-AKE is a synthetic version of a protein known as Waglerin 1. Waglerin 1, which is 21 amino acids in length, is a protein venom produced by the Malaysian Temple Viper (Tropidolaemus wagleri), a venomous snake found in southeast Asia. The venom of the Temple Viper can paralyze its prey by interfering with signaling between nerves and muscles. Syn-AKE does the same thing but in a controlled form. Syn-AKE is only three amino acids in length, making use of only the active portion of the Waglerin 1 protein. Note the play on the word “snake” in the Syn-AKE (pronounced “Sin ache”) name.

What Does Syn-AKE Do?

Syn-AKE is a competitive antagonist of the muscular nicotinic acetylcholine receptor [3]. Acetylcholine is the neurotransmitter used to send electrical signals from nerves to muscles. Without acetylcholine, muscles do not receive signals to contract and thus remain in a relaxed state. By blocking the acetylcholine receptor, Syn-AKE is able to block normal neuromuscular signaling and prevent muscle contractions. This, in turn, keeps facial muscles relaxed and can reduce

Syn-AKE Research on Smoothing Wrinkles

Preparations of Syn-AKE for topical application have been tested in animal models in concentrations that range from 1-4%. These preparations have produced excellent results, smoothing the appearance of mimic wrinkles and expression lines just a short time after the preparation is applied [2]. Research shows that Syn-AKE can reduce the appearance of wrinkles by up to 52% when a 4% topical solution is used [4]. This would make Syn-AKE more effective than Botox [5].

Storage Instructions:

All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping 3-4 months reconstituted (mixed with bacteriostatic water) to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.

Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you're ready to reconstitute it with bacteriostatic water.

Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4C (39F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.

However, for longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80C (-112F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide’s stability.